Featured Publications

Leveraging a deep bench of expertise and foundational experience in DNA medicine development, we’re driving research that has the potential to transform treatment paradigms and improve patients’ lives.

Infectious Diseases (Non HPV-Associated)

Title Disease Target Product
Synthetic Consensus HIV-1 DNA Induces Potent Cellular Immune Responses and Synthesis of Granzyme B, Perforin in HIV Infected Individuals
Molecular Therapy — March 2015
HIV-1 Env DNA Vaccine plus Protein Boost Delivered by EP Expands B- and T-Cell Responses and Neutralizing Phenotype In Vivo
PLoS ONE — December 2013
Immunogenicity of a novel engineered HIV-1 clade C synthetic consensus-based envelope DNA vaccine
Vaccine — September 2011
Intradermal SynCon® Ebola GP DNA Vaccine Is Temperature Stable and Safely Demonstrates Cellular and Humoral Immunogenicity Advantages in Healthy Volunteers
The Journal of Infectious Diseases — March 2019
Ebola INO-4201
Protective Efficacy and Long-Term Immunogenicity in Cynomolgus Macaques by Ebola Virus Glycoprotein Synthetic DNA Vaccines
The Journal of Infectious Diseases — October 2018
Ebola INO-4201
Rapid response to an emerging infectious disease – Lessons learned from development of a synthetic DNA vaccine targeting Zika virus
Microbes and Infection — December 2018
Zika INO-4600
Zika-Induced Male Infertility in Mice Is Potentially Reversible and Preventable by Deoxyribonucleic Acid Immunization
The Journal of Infectious Diseases — July 2018
Zika INO-4600
DNA vaccination protects mice against Zika virus-induced damage to the testes
Nature Communications — June 2017
Zika INO-4600
In vivo protection against ZIKV infection and pathogenesis through passive antibody transfer and active immunisation with a prMEnv DNA vaccine
npj Vaccines — November 2016
Zika INO-4600
A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates
Science Translational Medicine — August 2015
Broad cross-protective anti-hemagglutination responses elicited by influenza microconsensus DNA vaccine
Vaccine — May 2018
An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model
Nature Communications — September 2017
Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus
The Journal of Infectious Diseases — March 2016
Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy
Scientific Reports — July 2015
IFNL3-adjuvanted HCV DNA vaccine reduces regulatory T-cell frequency and increases virus-specific T-cell responses
Journal of Hepatology — February 2020
Hepatitis C GLS-6150
Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: a phase 1, open-label, single-arm, dose-escalation trial
The Lancet Infectious Diseases — July 2019
Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine — Preliminary Report
The New England Journal of Medicine — October 2017
Zika INO-4600
Phase I Trial of a Therapeutic DNA Vaccine for Preventing Hepatocellular Carcinoma from Chronic Hepatitis C Virus (HCV) Infection
Cancer Prevention Research — March 2023
Hepatocellular Carcinoma from Chronic HCV Infection INO-8000 + INO-9012